Published on: Sep 23, 2022

Primiparous sows are usually associated with poor lactation performance and low weaning weight piglets. Live yeast supplementation have been shown to improve sow health status, milk composition, and growth performance of suckling piglets. However, little is known about the carryover effects of live yeast supplementation during gestation and lactation on primiparous sows and their offspring.

In the present study[1], Live yeast supplementation significantly increased the serum concentrations of IgA and IgG of sows at farrowing and weaning stages, and of piglets at post-weaning.

These results suggest that live yeast addition in the diets of gestating and lactating primiparous sows might improve the maternal and progeny health by increasing the immunity of sows and their offspring.

Tian Xia 1,†, Chenggang Yin 1,†, Marcello Comi 2, Alessandro Agazzi 3 , Vera Perricone 3 , Xilong Li 1 and Xianren Jiang 1, Live Yeast Supplementation in Gestating and Lactating Primiparous Sows Improves Immune Response in Dams and Their Progeny in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137933/ 

The trial, conducted at the Tianpeng experimental farm, located in Langfang, wanted to investigate the effects of live yeast supplementation during middle–late gestation and the lactation period in primiparous sows on reproductive parameters, lactation performance, and immunity, and also explores the carryover effects in their offspring.

On day 60 of gestation, 16 crossbred primiparous sows were randomly assigned to two dietary treatments (with or without supplementation of live yeast) from day 60 of gestation to the end of lactation. The results showed that the addition of live yeast significantly increased the serum IgA and IgG concentrations of sows at farrowing and weaning stages and of piglets on day 14 and 28 post weaning.

The carryover effects of dietary supplementation had effects also on the percentage of diarrhoea incidence during post weaning day 0–14, that in the group treated with live yeast tended to be lower.

In conclusion, live yeast addition during middle–late gestation and the whole lactation period resulted in enhanced immunity of primiparous sows and their offspring, therefore, improving maternal and progeny health.

We are proud to announce the completion of three authorization renewals for the use in the European Union (EU). They concern the zootechnical feed additive Biosprint® (MUCL™39885), which received the authorization renewal for Dairy Cows, Horses, Sows and weaned piglets. All authorizations are valid for ten years.

“We are very pleased with these achievements –Emanuela Epis, Product Manager at Prosol explains – Our best-known animal feeding solutions like Biosprint® are in the market for 25 years and we continue investing so to achieve the highest quality standards and confirm great performance by supporting several scientific trials.”
PROSOL’s animal nutrition team is strongly committed to provide efficient solutions to the livestock operators not just in Europe, but in international markets as well.

Prosol’s authorizations published on EU Official Journal 2020/2021:

• Renewal of the use of the yeast Biosprint® in Dairy Cow and Horses – Commission Implementation on Official Journal of the European Union on 24th of July 2020 (EU 2020/1096)
• Renewal of the use of the yeast Biosprint® in Sows – Commission Implementation on Official Journal of the European Union on 24th of July 2020 (EU 2020/1094)
• Renewal of the use of the yeast Biosprint® in weaned piglets– Commission Implementation on Official Journal of the European Union on 24th of March 2021

SwineMod® is the results of many years of Prosol experience in yeast processing and yeast cell components efficacy knowledge, proven in in vitro and in vivo trials.

SwineMod® is a source of cell wall components such as glucans and mannans, and nucleotides, nucleosides, oligo nucleotides, ribonucleic acids fragments, peptides, aminoacids, minerals and group B vitamins. All these nutrients represent a pool of active and beneficial ingredients for piglets and sows wellbeing. Their synergic effect can modulate immune system response and help in reducing post weaning piglets gaps increasing feed intake and improving palatability.

SwineMod™ is the suitable solution for your antibiotic free program.

A precocious weaning, ( 3 weeks of age), as it usually done in rearing pigs, is crucial. The dramatic changes in the alimentary (rough passage from a warm mother’s milk to a cold and dry feed) and in the environment (sudden separation from the sow, transport and new social group) can have serious consequences for the digestive and immune functions of the pig’s intestine:

• Weight loss (up to 30%)
• Modifications in enzymatic pool
• Reduction in the length of intestinal villi height and the depth of the intestinal crypts
• Undigested feed becomes substrate for pathogens inflammation
• Diarrhea
• Negative effects on defensive responses against infectious diseases

The perinatal phase, the period before birth up to the third day after farrowing, is particularly sensitive phase in piglet production. The sows are stressed physiologically and due to behavioral restriction imposed by the farrowing crate system. Maternal glucocorticoids induced by prenatal stress have been shown to cross the placenta in pigs. This lead to a reduction in colostral milk and in IgG supply. This is important to minimize sows and piglets stress during the periparturient period.

Nucleotides are low-molecular-weight intracellular compounds that participate in numerous biochemical processes. They are composed of a nitrogenous base (pyrimidine or purine) linked to a pentose (ribose or deoxyribose) sugar to which one, two or three phosphate groups are attached.  Nucleotides are involved in several processes:

• nucleic acids precursors (RNA, DNA)
• protein synthesis
• cell turnover
• phospholipid synthesis
• coenzyme components
• iron absorption
• cell-mediated immune response

Nucleotides are safe, improve gastric development and early immune function and reduce digestive disorders in pigs post- weaning. Animal studies suggest that nucleotide supplementation can affect immune function by enhancing:

• mitogen-induced lymphocyte proliferation
• interleukin-2 production
• cell-mediated immunity
• enterocyte and lymphocyte maturation
• resistance to infection

Glucans are high molecular-weight substances composed of glucose as building blocks, usually isolated from cell walls of bacteria, mushrooms, algae, cereal grains, yeast and fungi. A number of animal studies suggest that Glucans reduce Pasteurella multocida, increase lymphocytes, increase haptoglobine, increase IL-10, decrease TNFα, alert immune system, at high dose are more pro inflammatory.

For additional information about the dosages or other questions about the brand SwineMod™, please contact Mrs. N. Pedretti, Marketing & Sales Director, Tel +39 035.99.16.65 – Fax +39 035.99.22.46

E-mail: prosol@prosol.it

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Ringø E, Olsen RE, Vecino JLG, Wadsworth S, Song SK (2012) Use of immunostimulants and nucleotides in aquaculture: a review. J Marine Sci Res Development 1:104.

Nadja Sauer, Rainer Mosenthin and Eva Bauer (2011) The role of dietary nucleotides in single-stomached animals Nutrition Research Reviews (2011), 24, 46–59

K.J. Rutherfurd-Markwick et al. (2013) The potential for enhancement of immunity in cats by dietary supplementation Vet. Immunology and Immunopathology 152 333– 340

Agazzi A, Caputo JM, Ferroni M, et al. (2013) Intestinal proinflammatory citokines could be modulated by dietary nucleotides in post weaning piglets Italian Journal of Animal Science vol 12 s1

Chiofalo B., Lo Presti V., Savoini G., D’Alessandro E., et al.(2011) Nucleotides in broiler chicken diet: effect on breast muscles quality. Czech J. Food Sci., 29: 308–317.