Prosol is pleased to announce its participation in Vitafoods Europe 2026, taking place in Barcelona from May 5 to 7. As one of the world’s leading global events for the nutraceutical industry, Vitafoods brings together ingredient innovators, finished product developers, and key players from across the international health and nutrition ecosystem.

A Portfolio Evolving with the Market

At this year’s edition, Prosol will present an expanded range of yeast-derived ingredients developed for nutraceutical applications.

The company will introduce:

• New application areas
• New market opportunities
• New clinical evidence

A highlight of the booth will be Prosol’s nucleotide-based ingredients, an innovative, unconventional and highly versatile category for brands looking to differentiate through science.

Reliable, Evidence-Based Solutions

Prosol’s specialties are designed to help formulators to:

• Enhance the quality of finished products
• Innovate with functional, science-supported solutions
• Reach new consumer targets and expand their product portfolio

Visitors will have the opportunity to explore Prosol’s full nutraceutical offering and discover how yeast biotechnology can support the development of next-generation formulations.

Meet the Team in Barcelona

Prosol will exhibit at Stand #3A256 at Fira de Barcelona, where the team will be available for technical discussions, ingredient insights, and personalized project support.

To schedule a meeting in advance, visitors are welcome to contact us directly.

Free Access Code

Access to the exhibition requires registration: https://www.vitafoods.eu.com/en/registration.html

A complimentary entry code is available for partners and visitors: VFEE81

Event Details

Location: Fira de Barcelona – Av. Joan Carles I, 64, 08908 Barcelona, Spain

Dates: May 5–7, 2026

Opening Hours:

• May 5: 9:30 AM – 6:00 PM
• May 6: 9:30 AM – 6:00 PM
• May 7: 9:30 AM – 4:00 PM

We are proud to announce the completion of three authorization renewals for the use in the European Union (EU). They concern the zootechnical feed additive Biosprint® (MUCL™39885), which received the authorization renewal for Dairy Cows, Horses, Sows and weaned piglets. All authorizations are valid for ten years.

“We are very pleased with these achievements –Emanuela Epis, Product Manager at Prosol explains – Our best-known animal feeding solutions like Biosprint® are in the market for 25 years and we continue investing so to achieve the highest quality standards and confirm great performance by supporting several scientific trials.”
PROSOL’s animal nutrition team is strongly committed to provide efficient solutions to the livestock operators not just in Europe, but in international markets as well.

Prosol’s authorizations published on EU Official Journal 2020/2021:

• Renewal of the use of the yeast Biosprint® in Dairy Cow and Horses – Commission Implementation on Official Journal of the European Union on 24th of July 2020 (EU 2020/1096)
• Renewal of the use of the yeast Biosprint® in Sows – Commission Implementation on Official Journal of the European Union on 24th of July 2020 (EU 2020/1094)
• Renewal of the use of the yeast Biosprint® in weaned piglets– Commission Implementation on Official Journal of the European Union on 24th of March 2021

To celebrate 45 years of experience and innovation, Prosol has launched a new version of its corporate website. Now it will be easier and faster to find information and news about Prosol products and ingredients.   

More engaging, more informative, more useful: the new Prosol web site is now officially on line.

Prosol has launched the new www.prosol.it to deliver an enhanced user experience for the company’s diverse audiences in accessing information. In addition to aesthetically re-designing, indeed, the new website also boasts a consistent site-wide navigation system with improved menu functionalities that direct you to the most relevant information for your needs and into the full product Prosol’s portfolio. The new website also offers new sections with technical articles, videos and event details.

-“We are pleased to announce the launch of our new website. Our new web home will allow an easier and faster access to all information and news about Prosol This new version will help us to improve our communication with our partners and stakeholders, providing them with evidence-based information on all products.” – said Nadia Pedretti, Prosol’s Marketing Director – “The launch of the new Prosol site this year was just the further step of our on line presence and we look forward to continuing this journey as well.” –

The site, completely mobile responsive to make easy to navigate also on mobile devices, shows the most commonly searched about products and ingredients, along with several new features to stay informed with the latest Prosol news and developments.

In particular, the new website includes:

• Updated navigation organized to help visitors easily to find ingredients for human or animal nutrition
• Resources page for quicker access to the blog, products information and videos;
• News & Events that highlight the latest company news
• Company Overview to take a look into Prosol

Come and explore the new Prosol website: www.prosol.it

PRESS CONTACT

Nadia Pedretti
Marketing Director
Tel: +39 035.99.16.65
Fax:+39 035.99.22.46
E-mail: prosol@prosol.it

Last week in Poland was held the 22nd European Symposium on Poultry Nutrition the event, organized by the World’s Poultry Science Association focused on the most recent advances poultry nutrition issues in Europe. During this event, Prosol had the opportunity to share some of its latest results in poultry nutrition in a scientific poster presentation exposed during the Symposium.

The poster highlighted the benefits of a new additive based on hydrolyzed yeast from Kluyveromyces fragilis (I-Care) on broilers performances. For more information about the study, please contact us.

On 27th and 28th of February 2019, Prosol attended the third edition of Nutraceuticals Europe – Summit & Expo. The event, which was held in the Palacio Municipal de Congresos de Madrid, housed over 100 companies of the nutraceutical sector and more than 2300 high-level professionals. As part of NTCEUROPE, Prosol talked at the Seminar Theatre program, the space where companies had the opportunity to share their latest releases and new challenges on nutraceutical products.

With a conference entitled “A natural perspective for the control of Alzheimer Disease”, our Business Development Manager, Alessandro Sgherbini, highlighted the beneficial effects of nucleotides on synaptic degeneration in Alzheimer Disease and in controlling the most common form of neurodegenerative disease.    We were pleased with the strong interest in our speech and ingredient solutions and to welcome partners and customers to our booth. We would like to thank Pharmafoods team and all our visitors and we look forward to continuing our dialogue with you!

A natural perspective for the control of Alzheimer Disease

The talk at the Seminar Theatre program of the fair was an opportunity to show the importance of nutraceuticals and nucleotides for the control of Alzheimer Disease.

Alzheimer’s disease is one of the most common form of dementia characterized by the deposition of extracellular amyloid-β (Aβ) peptides in the brain. The neuronal death, that characterizes this neurodegenerative disorder, causes irreversible cognitive impairment and behavioral alteration. Beside synthetic drugs, the use of natural-derived products and/or nutraceuticals could represent a future medical option in industrialized countries.  They are not proposed as an alternative to drugs, but instead, can be helpful to complement a pharmacological therapy and prevent the onset of chronic diseases. In this context, nucleotides have demonstrated to improve the clinical outcomes in immunosuppressive and inflammatory-based diseases.

Nucleotides are intracellular compounds involved in many biochemical pathways and nowadays, they are also included in different food supplements formulations targeted to immune system and nervous system. Few years ago, Prosol developed and launched in the market Ribodiet, that is a yeast extract standardized in free nucleotides content (>40%), but also source of AA, Mineral salts and group B vitamins, naturally occurring in the yeast cytoplasm.

A recent study[1] conducted at University of Naples Federico II Naples (Department of Pharmacy, School of Medicine and Surgery), indicated that the ribonucleotide-based formulation of Ribodiet, in a dose dependent manner, is able to revert the state of mnemonic decline and cognitive deficit typical of AD. This study suggests the potential role of Ribodiet as nutraceutical product useful for neurodegenerative disease such as AD, thanks to its anti-inflammatory and neuroprotective effect.

To learn more about Ribodiet please contact us:
Prosol S.p.a, Via Carso, 99 – 24040 MADONE (BG), Italy.
Tel +39 035.99.16.65
Fax +39 035.99.22.46
E-mail: prosol@prosol.it
website. www.prosol.it

© All Rights reserved

Published on: Jun 26, 2018

Ribodiet® is a Prosol new natural product extracted from yeast cell with standardized, highly controlled and gentle process organic solvent free.

Nucleotides have been commercially used in human infant formulas for many years, as a way of improving gastric development and early immune function. (Helembai et al., 2006; Ruihua et al., 2006).

Ribodiet® is a source of nucleotides, nucleosides, oligo nucleotides, ribonucleic acids fragments, aminoacids and vitamin B complex.  All these nutrients represent a pool of active and beneficial ingredients.

Nucleotides are low-molecular-weight intracellular compounds that participate in numerous biochemical processes. They consist of a nitrogenous base (pyrimidine or purine) linked to a pentose (ribose or deoxyribose) sugar to which one, two or three phosphate groups are attached.

In the cell nucleotides have several functions:

– Structural: Nucleic Acids (RNA, DNA)

– Carriers: energy transport (ATP, ADP, AMP)

– Co-enzymes: key role in synthesis of proteins, fats and carbohydrates metabolism

– Messengers: intracellular signal transduction

Nucleotide-free diets have been shown to impair cell-mediated and humoral immune responses; which include decreased macrophage and natural killer (NK) cell activity, delayed type hypersensitivity responses, cytokine levels, lower antibody production, all of which may lead to an increased susceptibility to infection (Gil, 2002; Sanchez-Pozo and Gil, 2002). These changes can be reversed by supplementation with nucleotides (Gil, 2002; Navarro et al., 1996).

About Ribodiet®

How benefit from nucleotide use

De novo synthesis does not satisfy the nucleotides requirements of many tissues and particular life physiological phases, making necessary a reinforcement by dietary source.

Particularly, some cells at high turn-over rate, such as gut, immune system and cerebral ones (lymphocytes, erythrocytes, bone marrow cells; glial cells) are not able to produce enough nucleotides to cover their needs

There is increasing evidence that dietary nucleotides may affect different aspects of body function and health in single-stomached animals, including:

• intestinal morphology and function
• immune response
• composition of the intestinal microbiota
• liver function and morphology

RIBODIET®.  Trial 1. Evaluation of Ribodiet® immunomodulatory activities on tratead human monocytes

After treatment with Ribodiet® and LPS stimulation all the results, assessed to be statistically significant, indicate that Ribodiet® showed those in vitro effects:

• anti- inflammatory
• immune- modulatory

RIBODIET® Trial 2.  Evaluation of anti-inflammatory activity of Ribodiet® in combination with other ingredients on treated human monocytes

After treatment with Ribodiet® in combination with Acerola (std. Vit C) and Zinc and LPS stimulation TNF –α levels are lower. Ribodiet®  boosts the anti-inflammatory activity of Acerola (std. Vit C) and Zn.

Ribodiet® improves the efficacy of ingredients with claims approved.

• Immune system
• Gut barrier Health
• Sport nutrition
• Cognition/Concentration
• Iron absorption

For comments, suggestions and additional information or related questions about the brand Ribodiet®, please contact Mrs. N. Pedretti, Marketing & Sales Director, Tel +39 035.99.16.65 – Fax +39 035.99.22.46  E-mail: prosol@prosol.it

Agazzi A, Caputo JM, et al. (2013) Intestinal proinflammatory citokines could be modulated by dietary nucleotides in post weaning piglets Italian Journal of Animal Science vol 12 s1

Chiofalo B., Lo Presti V., et al. (2011) Nucleotides in broiler chicken diet: effect on breast muscles quality. Czech J. Food Sci., 29: 308–317.

Domeneghini C, Di Giancamillo A, et al. (2004) Structural patterns of swine ileal mucosa following L-glutamine and nucleotide administration during the weaning period. An histochemical and histometrical study. Histol Histopathol 19, 49–58.

Gil, A., (2002) Modulation of the immune response mediated by dietary nucleotides. Eur. J. Clin. Nutr. 56 (S3), S1–S4.

Hess J R. and Greenberg N A. (2012) The Role of Nucleotides in the Immune and Gastrointestinal Systems : Potential Clinical Applications Nutr Clin Pract 2012 27: 281

Martinez-Augustin, O., Boza, J.J., et al. (1997) Dietary nucleotides may influence the humoral immunity in immunocompromised children. Nutrition 13, 465–469.

Navarro, J., Ruiz-Bravo, A., et al. (1996) Modulation of antibody-forming cell and mitogen-driven lymphoproliferative responses by dietary nucleotides in mice. Immunol. Lett. 53, 141–145.

Ortega MA, Gil A & Sanchez-Pozo A (1995) Maturation status of small intestine epithelium in rats deprived of dietary nucleotides. Life Sci 56, 1623–1630.

Rutherfurd-Markwicka et al. (2013) The potential for enhancement of immunity in cats by dietary supplementation Veterinary Immunology and Immunopathology 152 (2013) 333–340

Sanchez-Pozo A., Gil, A., 2002. Nucleotides as semiessential nutritional components. Br. J. Nutr. 87 (S1), S135–S137.

Sauer N, Mosenthin R et al. (2011) The role of dietary nucleotides in single-stomached animals Nutrition Research Reviews (2011), 24, 46–59

Efficient rumination in dairy cows increases the protein output and feed intake. High-density diets used are necessary to avoid negative energy balance, make the rumen more susceptible for disturbance. According to the literature Biosprint® results in an increase in efficiency of the fermentation. Rumen studies show:

• Less variation in rumen pH
• More cellulose fermentation
• Higher bacterial protein output

Results of 3 published dairy trials show average improvements of 4,5% in milk production and 3,7% in milk protein content.

50 Dairy cows were allocated to 2 treatments, based on production, stage and number of lactation. Cows were fed a mixed basal diet with corn and grass silage and a high protein corn silage supplement. 2 types of concentrates were provided to cows by a feed computer: 2 kg of starter supplement with/without Biosprint® and standard concentrate according to production. During the trial period of 104 days the following data are recorded:

• Intake of concentrate
• Milk production and composition

Results of 6 cows were not included for various reasons.

Biosprint® has most effect when fed as living yeast. To avoid pelleting losses, for this trial the yeast was pre-mixed with vegetable fat and added to ready pelleted feed.. Feed was transported as bulk and fed via a computer. Samples show good recovery and stability of the yeast, with no segregation of Yeast or any dust on the bottom of the silo.

Trial results show 5% higher milk production and 3,7% higher protein output. Cows fed with Biosprint® had lower somatic cell counts. The response was higher in cows earlier in lactation.

Biosprint® addition on ready-pelletted feed with vegetable oil shows good recovery and stability.

3 g Biosprint® / cow / day strongly improves protein / cow / day. Extra daily yield of 5% milk and 3,5 % protein have an extra value of more than € 0,35 / cow, while costs are less than € 0,03 / cow / day.

THIS MEANS THE RETURN ON INVESTMENT OF BIOSPRINT® IS MORE THAN 10:1

To learn more about Biosprint® trial data results please contact:

Mrs. N. Pedretti, Marketing & Sales Director, Tel +39 035.99.16.65 – Fax +39 035.99.22.46  

E-mail: prosol@prosol.it    

Web site: www.prosol.it

Ribonucleic acid is the molecule that transmits genetic information during cellular duplication phase. The function of this molecule is to “copy” DNA Nucleotides sequences, in order to transmit the information to the new cells.

Nucleic acids cover a primary role in the transmission of genetic information and in the cellular synthesis. Multiplication rate naturally changes because of different physiological phases, tissue type and nutrients availability.

Nucleotides are the constitutive units of DNA and RNA Nucleic Acids.

Nucleotides are true nutraceuticals or functional ingredients frequently used to improve the disease resistance, to decrease mortality and to promote the growth rate. They are widely utilized in clinical nutrition, in mother milk substitutes and in some integrators.

Nucleotides participate to different important physiological processes in the body.  As carriers, they allow the transport of ATP the main energetic molecule for the living cells. Moreover, they play a focal role in several enzymatic reactions, affecting proteins, fats and carbohydrates metabolism which together essential amino represent a key factor in the protein synthesis.

De-novo synthesis does not satisfy the Nucleotides requirements of many tissues and particular life physiological phases, making necessary a reinforcement by dietary source. Particularly, some cells at high turn-over rate, such as gut and immune system ones (lymphocytes, erythrocytes and bone marrow cells) are not able to produce enough Nucleotides to cover their needs. Numerous studies demonstrated that the inclusion of a suitable quantity of RNA or Nucleotides in the diet is of primary importance to face critical steps, such as the growing period and during the recovering after diseases problems.

Studies carried out on humans have shown that dietary inclusion of RNA and Nucleotides bring about different positive effects on different body tissues. The main are the following:

Immune system
Nucleotides show a positive effect on the immune system acting on two sides: the humoral immune response and the cell-mediated response.
For what concerns the first side, Nucleotides promote the lymphocytes B antibodies production (especially IgM), directly related to the dosage supplied.
Nucleotides dietary intake positive influences the local immune response, as indicated by IgA higher production.

Coming to the cell-mediated immune response, Nucleotides stimulate the proliferation, differentiation and maturation of neutrophils, increasing the pathogens resistance.

Furthermore, Nucleotides promote the proliferation of bone marrow cells, stimulate the production and secretion of interleukin-2 and interferon gamma and increase the cyto-toxicity of the natural killer cells.

The usage of Nucleotides alone or in combination with pharmaceuticals is very effective in case of chemotherapy, immuno-suppressive pathologies and organs transplantation. Treatment of Candida, Staphylococcus aureus and Cryptosporidiosis infections shown major effect.

In 2007 on British Journal of Nutrition has been published a meta-study which demonstrated that feeding infants with Nucleotides is associated to a better anti-bodies response to the vaccines Haemopillus influenza (P=0.001), diphtheria toxoid (P=0,001), oral antipolio vaccine (P=0,001). The data confirm the positive effects of Nucleotides inclusion without risk correlated.

9 studies conducted between 1991 and 2006 with low dosage (12-35 mg/L) and 6 studies between 1998 and 2004 with high dosage of nucleotides in the diet (72 mg/L) have registered an improvement of immune parameters and less diarrhoea events, with lower performances with mother milk feeding only.

In 2001, 2003, 2007 some studies collected and elaborated the results on different clinical experimentations conducted on several hospitalized subjects and feed with enteral foods.

Many single studies and at least five meta-studies about the combination of different immune-modulating components, among which Nucleotides, gave positive homogeneous results.

In particular a study conducted on 22 experimentations that involved approx. 2000 patients, demonstrated a positive connection between enteral nutrition with integration of immune-modulating substances (nucleotides, arginine, omega-3, glutamine) and the decrease of complications due to infections.

In 2003, a study reported that in patients with gastro-intestinal tumour, the pre and post operation nutrition with immune factors (RNA and Nucleotides) has reduced the gastro-intestinal side effects in post operation phase.

 

Dietary Nucleotides act as “growth factors” on the gut cells, promoting their differentiation and maturation: a higher thickness of intestinal mucosa and of villi and an increased activity of the digestive enzymes are subsequent to the benefit on the intestinal cells. Beside higher villi surface and crypts depth increase upon inclusion of Nucleotides in the diet.

Different studies have shown a higher nutrients intestinal absorption, specifically Calcium, Phosphorous and carotenoids.

Besides, Nucleotides act improving intestinal immune defences and promoting bacteria growth, mostly Lactobacilli and Bifidobacteria to the detriment of the Gram-negative bacteria, responsible of enteritis like Escherichia Coli.

Immediate results are a higher disease and infections resistance, besides a more rapid recovery of enteritis and nutritional or protein privation.

Recent meta-studies on different clinical researches pointed out less diarrhoea events and an improvement of the composition of intestinal flora in comparison with subjects fed with milk not added with Nucleotides.

Various in vitro studies demonstrated the beneficial Nucleotides effect on Bifidobacteria. The reason of this effect could be due to the increase of ion Iron absorption, ion that promotes the development of Enterobacteria in the intestine and the fact that Nucleotides are a growth factor for Bifidobacteria, although overall, Nucleotides are absorbed as Nucleosides in the first gut tract. It seems that a percentage of approx. 10% of the dietary Nucleotides is present in the colon and there exercises its growing effect on Bifidobacteria.

A Nucleotides rich diet is very useful in the clinical and functional recovery of hepatic infections; actually, after hepatic intoxications, fibrosis and cirrhosis, the entity of

the damage is lower and the recovery is faster. The facts are that Nucleotides promote the hepatic activity, speeding up the protein synthesis, the glucose deposit, stopping cholesterol and other lipids storage.

The cerebral cells are not able to synthesize Nucleotides; therefore, the dietary supply is focal for the central nervous system. Nucleotides stimulate the glial cells proliferation, promote the cerebral vascular circulation and improve the lipid metabolism of the cerebral cortex. As consequence memory and learning improvements are naturally occurring, overall in elderly subjects.

Maternal milk composition is one of the primary reference point for the formulation of infant foods. Data of maternal milk Nucleotides content are often not in accordance as they change because of the used analytical method, the lactation phase and whether RNA or nucleosides content is included or not in the calculation.

Maternal mature milk contains around 10 mg/L total Nucleotides present in different ratio depending of lactation phase, while bovine milk contains less Nucleotides and in different ratio, furthermore its heat treatment degrades the most of Nucleotides.

Nucleotides addition to infant milk is nowadays common for most of the market leaders and represents a standard supplementation in nutrition of new born up to 6 months age and even further.

The feeding of hospitalized patients it is very important, above all in critical situations as intensive therapy and post-surgery recovery.

The enrichment of enteral feeding with ingredients as Nucleotides, amino acids, fatty acids, omega-3 represents an effective support for the restore of the functionality of gastro-intestinal tract and to the stimulation of immunity response.

From the 1960 the characterization of the primary role developed by intestinal tract for the immunity response, determined a strong research in the pharmaceutical sector of the “most adapt formulation” for every specific clinical case and shelter phase.

Nestlè-Novartis, Mead Johnson, Abbott are names of the main pharmaceutical factories engaged in the research, formulation and production of enteral nutrition preparations.

A large numbers of recent clinical study, demonstrate the advantages of enriched and complete formulations use in comparison with standard-protein ones, utilized sometimes in pre-shelter phase.

The main are:

• Infections decrease
• A better post-operation recover and in case of diseases
• Shelter duration decrease

The new frontier of Nucleotides application is dietary supplements as immune-nutrients. The use of industrially produced foods changed the nutrition pattern.

Allergies, intolerances and metabolic disease rapidly grew in last decades, drawing more and more life quality, public and family sanitary cost. Foods composition and education strongly connect with these changes.

We hope that all the operators can use the clinical studies to verify RNA and Nucleotides functional properties in different operating conditions  and then offer to the consumers an effective support for a more complete and balanced nutrition.

On the market, we can find RNA and Nucleotides capsules apt to increase immunity response, digestive function and intestine health treating diarrhoea.

The dosages are obtained by studies conducted on the estimate of consumes in the first pregnancy and for adults subjects are approx. 50 – 200 mg/d of single Nucleotides based on age and physiological statement.

There is a clear demonstration that Nucleotides addition to aquaculture diet improves the health of fishes, the resistance to different bacterial infections, limiting the diffusion of diseases, that, in these types of breeding, cause huge economic damages.

Nucleotides have also an intensive anti-stress action, which has a particular positive effect in any intensive breeding.

INFANT FORMULA

European Directive 2006/141/CE allows the use Nucleotides in infant milk at the maximum dosage of 5 mg/100 kcal. In the United States, Life Sciences Research Office (LSRO) allows to use until 16 mg/100 kcal (www.lsro.org). Italian Department of Health allows the use of Nucleotides in the production of supplements and regulates the composition of infant formula under the Decree nr 62 of April 9, 2009 (www.salute.gov.it).

Claim requests for different functional properties related to the use of Nucleotides are under EFSA scrutiny.

DIETARY SUPPLEMENTS

Italian Department of Health allows using Nucleotides in the production of supplements (on the website www.salute.gov.it there is the list of the substances with nutritive and physiological effects admitted for in dietary supplements).EFSA is examining some claims requests for different functional properties related to the use of Nucleotides.